鏈珯瀹㈡埗鏈嶅嫏(w霉)铏�
鐠�(hu谩n)淇濆湪绶氬畼寰�
鐠�(hu谩n)淇濆湪绶氭墜姗�(j墨)鐗�
鐠�(hu谩n)淇濆湪绶欰PP
鐠�(hu谩n)淇濆湪绶氬皬绋嬪簭
绱�(j矛)瀵э紙涓婃捣锛夌鐮旇│鍔戠稉(j墨ng)閵峰晢浣滆��
闆濼oll妯ｅ彈楂�5閰惰伅(li谩n)鍏嶇柅鍒嗘瀽瑭﹀姂鐩掍娇鐢ㄨ鏄庢浉
| 璩囨枡椤炲瀷 | doc鏂囦欢 | 璩囨枡澶у皬 | 111104 |
| 涓嬭級娆℃暩(sh霉) | 28 | 璩囨枡鍦栫墖 | 銆愰粸鎿婃煡鐪嬨�� |
| 涓� 鍌� 浜� | 绱�(j矛)瀵э紙涓婃捣锛夌鐮旇│鍔戠稉(j墨ng)閵峰晢 | 闇�瑕佺⿳鍒� | 0 |
| 闂�(gu膩n) 閸� 瑭� | 闆濼oll妯ｅ彈楂�5閰惰伅(li谩n)鍏嶇柅鍒嗘瀽瑭﹀姂鐩掍娇鐢ㄨ鏄庢浉 | ||
- 銆愯硣鏂欑啊浠嬨��
闆濼oll妯ｅ彈楂�5(TLR5)閰惰伅(li谩n)鍏嶇柅鍒嗘瀽瑭﹀姂鐩掍娇鐢ㄨ鏄庢浉
浣跨敤鐩殑锛�
鏈│鍔戠洅鐢ㄤ簬娓畾闆炶娓呫�佽婕垮強鐩搁棞(gu膩n)娑查珨妯ｆ湰涓墰Toll妯ｅ彈楂�5(TLR5)鍚噺銆�
瀵﹂鍘熺悊
闆濼oll妯ｅ彈楂�5閰惰伅(li谩n)鍏嶇柅鍒嗘瀽瑭﹀姂鐩掍娇鐢ㄨ鏄庢浉鎳�(y墨ng)鐢ㄩ洐鎶楅珨澶惧績娉曟脯瀹氭(bi膩o)鏈腑闆濼oll妯ｅ彈楂�5(TLR5)姘村钩銆傜敤绱斿寲鐨勯洖Toll妯ｅ彈楂�5(TLR5)鎶楅珨鍖呰寰瓟鏉匡紝鍒舵垚鍥虹浉鎶楅珨锛屽線鍖呰鍠姉鐨勫井瀛斾腑渚濇鍔犲叆Toll妯ｅ彈楂�5(TLR5)锛屽啀鑸嘓RP妯�(bi膩o)瑷樼殑Toll妯ｅ彈楂�5(TLR5)鎶楅珨绲�(ji茅)鍚堬紝褰㈡垚鎶楅珨-鎶楀師-閰舵(bi膩o)鎶楅珨寰�(f霉)鍚堢墿锛岀稉(j墨ng)閬�*娲楁粚鍚庡姞搴曠墿TMB椤壊銆俆MB鍦℉RP閰剁殑鍌寲涓嬭綁(zhu菐n)鍖栨垚钘�(l谩n)鑹诧紝骞跺湪閰哥殑浣滅敤涓嬭綁(zhu菐n)鍖栨垚zui绲傜殑榛冭壊銆傞鑹茬殑娣辨泛鍜屾ǎ鍝佷腑鐨凾oll妯ｅ彈楂�5(TLR5)鍛堟鐩搁棞(gu膩n)銆傜敤閰舵(bi膩o)鍎�鍦�450nm娉㈤暦涓嬫脯瀹氬惛鍏夊害锛圤D鍊硷級锛岄�氶亷妯�(bi膩o)婧�(zh菙n)鏇茬窔瑷堢畻妯ｅ搧涓洖Toll妯ｅ彈楂�5(TLR5)婵冨害銆�
瑭﹀姂鐩掔祫鎴�
1 20鍊嶆績绺礂婊屾恫 20ml脳1鐡� 7 绲傛娑� 3ml脳1鐡�
2 閰舵(bi膩o)瑭﹀姂 3ml脳1鐡� 8 妯�(bi膩o)婧�(zh菙n)鍝侊紙24ng/mL锛� 0.5ml脳1鐡�
3 閰舵(bi膩o)鍖呰鏉� 12瀛斆�4姊� 9 妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫 1.5ml脳1鐡�
4 妯ｅ搧绋�閲嬫恫 3ml脳1鐡� 10 瑾槑鏇� 1浠�
5 椤壊鍔慉娑� 3ml脳1鐡� 11 灏佹澘鑶� 2寮�
6 椤壊鍔態娑� 3ml脳1/鐡� 12 瀵嗗皝琚� 1鍊�
妯�(bi膩o)鏈姹�
1锛庢(bi膩o)鏈噰闆嗗悗鐩℃棭閫�(j矛n)琛屾彁鍙栵紝鎻愬彇鎸夌浉闂�(gu膩n)鏂囩嵒(xi脿n)閫�(j矛n)琛岋紝鎻愬彇鍚庢噳(y墨ng)鐩″揩閫�(j矛n)琛屽椹椼�傝嫢涓嶈兘棣笂閫�(j矛n)琛岃│椹楋紝鍙皣妯�(bi膩o)鏈斁浜�-20鈩冧繚瀛橈紝浣嗘噳(y墨ng)閬垮厤鍙嶅京(f霉)鍑嶈瀺
2锛庝笉鑳芥娓惈NaN3鐨勬ǎ鍝侊紝鍥燦aN3鎶戝埗杈ｆ牴閬庢哀鍖栫墿閰剁殑锛圚RP锛夋椿鎬с��
鎿嶄綔姝ラ
1.妯�(bi膩o)婧�(zh菙n)鍝佺殑绋�閲嬶細鏈│鍔戠洅鎻愪緵鍘熷�嶆(bi膩o)婧�(zh菙n)鍝佷竴鏀紝鐢ㄦ埗鍙寜鐓т笅鍒楀湒琛ㄥ湪灏忚│绠′腑閫�(j矛n)琛岀█閲嬨��
12ng/mL 5铏熸(bi膩o)婧�(zh菙n)鍝� 150渭l鐨勫師鍊嶆(bi膩o)婧�(zh菙n)鍝佸姞鍏�150渭l妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫
6ng/mL 4铏熸(bi膩o)婧�(zh菙n)鍝� 150渭l鐨�5铏熸(bi膩o)婧�(zh菙n)鍝佸姞鍏�150渭l妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫
3ng/mL 3铏熸(bi膩o)婧�(zh菙n)鍝� 150渭l鐨�4铏熸(bi膩o)婧�(zh菙n)鍝佸姞鍏�150渭l妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫
1.5ng/mL 2铏熸(bi膩o)婧�(zh菙n)鍝� 150渭l鐨�3铏熸(bi膩o)婧�(zh菙n)鍝佸姞鍏�150渭l妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫
0.75ng/mL 1铏熸(bi膩o)婧�(zh菙n)鍝� 150渭l鐨�2铏熸(bi膩o)婧�(zh菙n)鍝佸姞鍏�150渭l妯�(bi膩o)婧�(zh菙n)鍝佺█閲嬫恫
2.鍔犳ǎ锛氬垎鍒ヨō(sh猫)绌虹櫧瀛旓紙绌虹櫧灏嶇収瀛斾笉鍔犳ǎ鍝佸強閰舵(bi膩o)瑭﹀姂锛屽叾浣欏悇姝ユ搷浣滅浉鍚岋級銆佹(bi膩o)婧�(zh菙n)瀛斻�佸緟娓ǎ鍝佸瓟銆傚湪閰舵(bi膩o)鍖呰鏉夸笂妯�(bi膩o)婧�(zh菙n)鍝佹簴(zh菙n)纰哄姞妯�50渭l锛屽緟娓ǎ鍝佸瓟涓厛鍔犳ǎ鍝佺█閲嬫恫40渭l锛岀劧鍚庡啀鍔犲緟娓ǎ鍝�10渭l锛堟ǎ鍝亃ui绲傜█閲嬪害鐐�5鍊嶏級銆傚姞妯ｅ皣妯ｅ搧鍔犱簬閰舵(bi膩o)鏉垮瓟搴曢儴锛岀洝閲忎笉瑙稿強瀛斿锛岃紩杓曟檭鍕曟贩鍕汇��
3.婧偛锛氱敤灏佹澘鑶滃皝鏉垮悗缃�37鈩冩韩鑲�30鍒嗛悩銆�
4.閰嶆恫锛氬皣20鍊嶆績绺礂婊屾恫鐢ㄨ捀椁炬按20鍊嶇█閲嬪悗鍌欑敤
5.娲楁粚锛氬皬蹇冩彮鎺夊皝鏉胯啘锛屾鍘绘恫楂旓紝鐢╁共锛屾瘡瀛斿姞婊挎礂婊屾恫锛岄潨缃�30绉掑悗妫勫幓锛屽姝ら噸寰�(f霉)5娆★紝鎷嶅共銆�
6.鍔犻叾锛氭瘡瀛斿姞鍏ラ叾妯�(bi膩o)瑭﹀姂50渭l锛岀┖鐧藉瓟闄ゅ銆�
7.婧偛锛氭搷浣滃悓3銆�
8.娲楁粚锛氭搷浣滃悓5銆�
9.椤壊锛氭瘡瀛斿厛鍔犲叆椤壊鍔慉50渭l锛屽啀鍔犲叆椤壊鍔態50渭l锛岃紩杓曢渿钑╂贩鍕伙紝37鈩冮伩鍏夐’鑹�15鍒嗛悩.
10.绲傛锛氭瘡瀛斿姞绲傛娑�50渭l锛岀祩姝㈠弽鎳�(y墨ng)锛堟鏅傝棈(l谩n)鑹茬珛杞�(zhu菐n)榛冭壊锛夈��
11.娓畾锛氫互绌虹櫧绌鸿(di脿o)闆讹紝450nm娉㈤暦渚濆簭娓噺鍚勫瓟鐨勫惛鍏夊害锛圤D鍊硷級銆� 娓畾鎳�(y墨ng)鍦ㄥ姞绲傛娑插悗15鍒嗛悩浠ュ収(n猫i)閫�(j矛n)琛屻��
鎿嶄綔绋嬪簭绺界祼(ji茅)锛�
瑷堢畻
闆濼oll妯ｅ彈楂�5閰惰伅(li谩n)鍏嶇柅鍒嗘瀽瑭﹀姂鐩掍娇鐢ㄨ鏄庢浉浠ユ(bi膩o)婧�(zh菙n)鐗╃殑婵冨害鐐烘┇鍧愭(bi膩o)锛孫D鍊肩偤绺卞潗妯�(bi膩o)锛屽湪鍧愭(bi膩o)绱欎笂绻嚭妯�(bi膩o)婧�(zh菙n)鏇茬窔锛屾牴鎿�(j霉)妯ｅ搧鐨凮D鍊肩敱妯�(bi膩o)婧�(zh菙n)鏇茬窔鏌ュ嚭鐩告噳(y墨ng)鐨勬績搴︼紱鍐嶄箻浠ョ█閲嬪�嶆暩(sh霉)锛涙垨鐢ㄦ(bi膩o)婧�(zh菙n)鐗╃殑婵冨害鑸嘜D鍊艰▓绠楀嚭妯�(bi膩o)婧�(zh菙n)鏇茬窔鐨勭洿绶氬洖姝告柟绋嬪紡锛屽皣妯ｅ搧鐨凮D鍊间唬鍏ユ柟绋嬪紡锛岃▓绠楀嚭妯ｅ搧婵冨害锛屽啀涔樹互绋�閲嬪�嶆暩(sh霉)锛屽嵆鐐烘ǎ鍝佺殑瀵﹂殯婵冨害銆�
娉ㄦ剰浜嬮爡
1锛庤│鍔戠洅寰炲喎钘忕挵(hu谩n)澧冧腑鍙栧嚭鎳�(y墨ng)鍦ㄥ婧钩琛�15-30鍒嗛悩鍚庢柟鍙娇鐢紝閰舵(bi膩o)鍖呰鏉块枊灏佸悗濡傛湭鐢ㄥ畬锛屾澘姊濇噳(y墨ng)瑁濆叆瀵嗗皝琚嬩腑淇濆瓨銆�
2锛庢績娲楁粚娑插彲鑳芥渻鏈夌祼(ji茅)鏅舵瀽鍑猴紝绋�閲嬫檪鍙湪姘存荡涓姞婧姪婧讹紝娲楁粚鏅備笉褰遍熆绲�(ji茅)鏋溿��
3锛庡悇姝ュ姞妯ｅ潎鎳�(y墨ng)浣跨敤鍔犳ǎ鍣紝骞剁稉(j墨ng)甯告牎灏嶅叾婧�(zh菙n)纰烘�э紝浠ラ伩鍏嶈│椹楄宸�備竴娆″姞妯ｆ檪闁撴帶鍒跺湪5鍒嗛悩鍏�(n猫i)锛屽妯�(bi膩o)鏈暩(sh霉)閲忓锛�*浣跨敤鎺掓鍔犳ǎ銆�
4锛庤珛姣忔娓畾鐨勫悓鏅傚仛妯�(bi膩o)婧�(zh菙n)鏇茬窔锛屽仛寰�(f霉)瀛斻�傚妯�(bi膩o)鏈腑寰呮脯鐗╄唱(zh矛)鍚噺閬庨珮锛堟ǎ鏈琌D鍊煎ぇ浜庢(bi膩o)婧�(zh菙n)鍝佸瓟*瀛旂殑OD鍊硷級锛岃珛鍏堢敤妯ｅ搧绋�閲嬫恫绋�閲嬩竴瀹氬�嶆暩(sh霉)锛坣鍊嶏級鍚庡啀娓畾锛岃▓绠楁檪璜媧ui鍚庝箻浠ョ附绋�閲嬪�嶆暩(sh霉)锛埫梟脳5锛夈��
5锛庡皝鏉胯啘鍙檺涓�娆℃�т娇鐢紝浠ラ伩鍏嶄氦鍙夋薄鏌撱��
6锛庡簳鐗╄珛閬垮厜淇濆瓨銆�
7锛庡毚(y谩n)鏍兼寜鐓ц鏄庢浉鐨勬搷浣滈��(j矛n)琛岋紝瑭﹂绲�(ji茅)鏋滃垽瀹氬繀闋堜互閰舵(bi膩o)鍎�璁�鏁�(sh霉)鐐烘簴(zh菙n).
8锛庢墍鏈夋ǎ鍝侊紝娲楁粚娑插拰鍚勭ó寤㈡鐗╅兘鎳�(y墨ng)鎸夊偝鏌撶墿铏曠悊銆�
9锛庢湰瑭﹀姂涓嶅悓鎵硅櫉绲勫垎涓嶅緱娣风敤銆�
10. 濡傝垏鑻辨枃瑾槑鏇告湁鐣帮紝浠ヨ嫳鏂囪鏄庢浉鐐烘簴(zh菙n)銆�
淇濆瓨姊濅欢鍙婃湁鏁堟湡
1锛庤│鍔戠洅淇濆瓨锛氾紱2-8鈩冦��
2锛庢湁鏁堟湡锛�6鍊嬫湀
2024涓栫挵(hu谩n)鏈冦�愬伐妤�(y猫)绡�(ji茅)鑳借垏鐠�(hu谩n)淇濆睍銆�
div6鏈�3鏃ワ紝2024涓栫挵(hu谩n)鏈冦�愬伐妤�(y猫)绡�(ji茅)鑳借垏鐠�(hu谩n)淇濆睍銆戜簬涓婃捣涓ㄥ湅瀹舵渻灞曚腑[瑭崇窗(x矛)]
- 鍑℃湰缍�(w菐ng)娉ㄦ槑"渚嗘簮锛氱挵(hu谩n)淇濆湪绶�"鐨勬墍鏈変綔鍝侊紝鐗堟瑠(qu谩n)鍧囧爆浜庣挵(hu谩n)淇濆湪绶氾紝杞�(zhu菐n)杓夎珛蹇呴爤娉ㄦ槑鐠�(hu谩n)淇濆湪绶氾紝http://www.hezebar.com銆傞仌鍙嶈�呮湰缍�(w菐ng)灏囪拷绌剁浉闂�(gu膩n)娉曞緥璨�(z茅)浠汇��
- 浼佹キ(y猫)鐧�(f膩)甯冪殑鍏徃鏂拌仦銆佹妧琛�(sh霉)鏂囩珷銆佽硣鏂欎笅杓夌瓑鍏�(n猫i)瀹癸紝濡傛秹鍙婁镜娆�(qu谩n)銆侀仌瑕�(gu墨)閬姇瑷寸殑锛屼竴寰嬬敱鐧�(f膩)甯冧紒妤�(y猫)鑷鎵挎摂(d膩n)璨�(z茅)浠伙紝鏈恫(w菐ng)鏈夋瑠(qu谩n)鍒櫎鍏�(n猫i)瀹瑰苟杩芥函璨�(z茅)浠汇��
- 鏈恫(w菐ng)杞�(zhu菐n)杓夊苟娉ㄦ槑鑷叾瀹冧締婧愮殑浣滃搧锛岀洰鐨勫湪浜庡偝閬炴洿澶氫俊鎭紝骞朵笉浠ｈ〃鏈恫(w菐ng)璐婂悓鍏惰榛炴垨璀夊鍏跺収(n猫i)瀹圭殑鐪熷鎬э紝涓嶆壙鎿�(d膩n)姝ら浣滃搧渚垫瑠(qu谩n)琛岀偤鐨勭洿鎺ヨ铂(z茅)浠诲強閫ｅ付璨�(z茅)浠汇�傚叾浠栧獟楂斻�佺恫(w菐ng)绔欐垨鍊嬩汉寰炴湰缍�(w菐ng)杞�(zhu菐n)杓夋檪锛屽繀闋堜繚鐣欐湰缍�(w菐ng)娉ㄦ槑鐨勪綔鍝佷締婧愶紝骞惰嚜璨�(f霉)鐗堟瑠(qu谩n)绛夋硶寰嬭铂(z茅)浠汇��
- 濡傛秹鍙婁綔鍝佸収(n猫i)瀹广�佺増娆�(qu谩n)绛夊晱椤岋紝璜嬪湪浣滃搧鐧�(f膩)琛ㄤ箣鏃ヨ捣涓�鍛ㄥ収(n猫i)鑸囨湰缍�(w菐ng)鑱�(li谩n)绯伙紝鍚﹀墖瑕栫偤鏀炬鐩搁棞(gu膩n)娆�(qu谩n)鍒┿��
鐠�(hu谩n)淇濆湪绶欰PP
鐠�(hu谩n)淇濆湪绶氬皬绋嬪簭
寰俊鍏溇铏�
